Gulten, Sirin2025-01-272025-01-2720130022-152X1943-5193https://doi.org/10.1002/jhet.980https://hdl.handle.net/20.500.12428/21493Biologically important 12 new important 3,4-dihydropyrimidin-2-(1H)-ones (-thiones) were synthesized with in one-pot three-component Biginelli reaction from the corresponding aromatic aldehydes (5-methyl-2-thiophenecarboxaldehyde and 2-chloro-5-nitrobenzaldehyde), -keto esters (ethylacetoacetate, allylacetoacetate, and t-butylacetoacetate), and urea/thiourea in the presence of catalytic amount of magnesium bromide and magnesium chloride hexahydrate as nontoxic, inexpensive, and easily available catalysts under solvent-free conditions at 80 and 100 degrees C. Compared with the catalyst-free three-component Biginelli reaction conditions, this method consistently has the advantage of short reaction time (45100 min) and good to excellent yields (7591%).eninfo:eu-repo/semantics/closedAccessCalcium-Channel BlockersSmall-Molecule InhibitorAcid-EstersConformational-AnalysisMitotic KinesinEfficientDerivativesFacile3,4-Dihydropyrimidin-2-(1h)-Ones3-ComponentArticle50239139510.1002/jhet.980Q3WOS:0003182930000342-s2.0-84876938396Q2