Turgut, BurakMercan, KadirIlhan, NevinDemır, NesrinCatak, Onur2025-01-272025-01-2720211305-91732717-7157https://doi.org/10.37844/glauc.cat.2021.16.10https://search.trdizin.gov.tr/tr/yayin/detay/510951https://hdl.handle.net/20.500.12428/16762Purpose: To evaluate the levels of salusin-beta (?-Sal) in the serum in patients with open-angle glaucoma.\rMaterials and Methods: This pilot work was designed as an institutional controlled comparative clinical study. The serum ?-Sal levels of age\rand sex-matched 20 healthy volunteers as controls (Group 1), 15 patients with normal-tension glaucoma (NTG) (Group 2), 18 patients with\rpseudoexfoliative glaucoma (PXG) (Group 3) and 26 patients with primary open-angle glaucoma (POAG) (Group 4) were measured with the\renzyme-linked immunosorbent assay (ELISA) method.\rResults: There was no statistically signifi cant difference concerning age and gender among the groups (p>0. 05). The mean serum ?-Sal levels\rin Group 1, Group 2, Group 3 and Group 4 were 4977.02±3741.44 pg/mL; 1086.57±253.41 pg/mL; 1044.98±268.80 pg/mL and 868.32±181.78\rpg/mL, respectively. Although the mean ?-Sal levels in all glaucoma groups seem numerically lower than the control group, there was no\rstatistically signifi cant difference between the serum ?-Sal concentrations of the study groups (p>0.05).\rConclusion: These fi ndings suggest that serum salusin-? levels are not different among various open-angle glaucoma types. However,\rtheoretically, ?-Sal may contribute to the pathogenesis of glaucoma and may play a neuroprotective hormone in glaucoma. Further studies with\rlarge patient population are required to say whether ?-Sal plays a role in the pathogenesis of glaucomatous optic neuropathy.eninfo:eu-repo/semantics/openAccessTıbbi Araştırmalar DeneyselGöz HastalıklarıArticle161535710.37844/glauc.cat.2021.16.10510951