Ekici, SemaIlgın, PınarYılmaz, SelahattinAktaş, NahitŞahiner, Nurettin2025-01-272025-01-2720110169-43321873-5584https://doi.org/10.1016/j.apsusc.2010.10.040https://hdl.handle.net/20.500.12428/23696We report the preparation and characterization of thiolated-temperature-responsive hyaluronic acid-cysteamine-N-isopropyl acrylamide (HA-CYs-NIPAm) particles and thiolated-magnetic-responsive hyaluronic acid (HA-Fe-CYs) particles. Linear hyaluronic acid (HA) crosslinked with divinyl sulfone as HA particles was prepared using a water-in-oil micro emulsion system which were then oxidized HA-O with NaIO4 to develop aldehyde groups on the particle surface. HA-O hydrogel particles were then reacted with cysteamine (CYs) which interacted with aldehydes on the HA surface to form HA particles with cysteamine (HA-CYs) functionality on the surface. HA-CYs particles were further exposed to radical polymerization with NIPAm to obtain temperature responsive HA-CYs-NIPAm hydrogel particles. To acquire magnetic field responsive HA composites, magnetic iron particles were included in HA to form HA-Fe during HA particle preparation. HA-Fe hydrogel particles were also chemically modified. The prepared HA-CYs-NIPAm demonstrated temperature dependent size variations and phase transition temperature. HA-CYs-NIPAm and HA-Fe-CYs particles can be used as drug delivery vehicles. Sulfamethoxazole (SMZ), an antibacterial drug, was used as a model drug for temperature-induced release studies from these particles. (C) 2010 Elsevier B.V. All rights reserved.eninfo:eu-repo/semantics/closedAccessTemperature-sensitive HA particlesMagnetic compositeDrug releaseModifiable HA particlesArticle25772669267610.1016/j.apsusc.2010.10.040Q1WOS:0002859632000442-s2.0-79251598944Q1