Sezer, BerkantKodaman Dokumacıgil, NurKaya, RemziyeGüven, SerçinTürkkan, Özde NisaÇiçek, NeslihanAlpay, HarikaKargül, Betül2023-08-212023-08-212023Sezer, B., Dokumacıgil, N. K., Kaya, R., Güven, S., Türkkan, Ö. N., Çiçek, N., … Kargül, B. (2023). Association between serum biomarkers and oral health status in children with chronic kidney disease: A cross-sectional study. Clinical Oral Investigations, 27(7), 3731–3740. https://doi.org/10.1007/s00784-023-04989-11432-69811436-3771https://doi.org/10.1007/s00784-023-04989-1https://hdl.handle.net/20.500.12428/4477Objectives: The aim of this study was to investigate the association between serum biomarkers and oral health parameters in children with chronic kidney disease (CKD). Materials and methods: Serum hemoglobin, blood urea nitrogen, serum creatinine, calcium, parathormone, magnesium, and phosphorus levels were measured in 62 children with CKD aged between 4 and 17 years. Intraoral examinations of the patients were performed by two different pediatric dentists. Dental caries was assessed using the decayed-missing-filled-teeth (DMFT/dmft) indexes, and oral hygiene was assessed using the debris (DI), calculus (CI), and simplified oral hygiene (OHI-S) indexes. Spearman’s rho coefficient and generalized linear modeling were used to examine the association between serum biomarkers and oral health parameters. Results: The results of the study showed that there were negative and statistically significant correlations between serum hemoglobin and creatinine levels and dmft scores in pediatric patients with CKD (p = 0.021 and p = 0.019, respectively). Furthermore, blood urea nitrogen levels and DI and OHI-S scores (p = 0.047 and p = 0.050, respectively); serum creatinine levels and DI, CI, and OHI-S scores (p = 0.005, p = 0.047, p = 0.043, respectively); and parathormone levels and CI and OHI-S scores (p = 0.001 and p = 0.017, respectively) were found to be positively and statistically significantly related. Conclusions: There are associations between various serum biomarker levels and dental caries and oral hygiene parameters in pediatric patients with CKD. Clinical relevance: The impact of changes in serum biomarkers on oral and dental health is important for dentists’ and medical professionals' approaches to patients' oral and systemic health.eninfo:eu-repo/semantics/closedAccessBiomarkersChronic kidney diseaseDental calculusDental cariesArticle2773731374010.1007/s00784-023-04989-1Q2WOS:0009630529000032-s2.0-8515152711037014503