Arslan, Yavuz EmreHiz, Meliha MerveSezgin Arslan, Tugba2025-01-272025-01-2720151300-6045https://doi.org/10.9775/kvfd.2014.11663https://search.trdizin.gov.tr/tr/yayin/detay/165383https://hdl.handle.net/20.500.12428/24535Human adipose-derived mesenchymal stem cells are nonhematopoietic cells found in the adipose tissue that have multipotent characteristics. Human adipose-derived mesenchymal stem cells have ability to differentiate into multiple lineages, including osteogenic, adipogenic and chondrogenic phenotypes. Because of their high degree of plasticity and ease of isolation, they have a great potential for tissue engineering and regenerative medicine applications. Tissue engineering, using cells, soluble matriks-bound factors and supporting scaffolds, is a promising approach for regeneration, repairing and replacement of malfunctioning tissues and organs. Three-dimensional scaffolds are essential to serve as an adhesive substrate for the transplanted cells and a physical support to guide the formation of new tissues or organs. Particularly, the use of extracellular matrices prepared by decellularized whole tissue and organ as three-dimensional constructs have drawn increasing attention as a tissue engineering strategy. In this context, it is expected that investigating the cellular behaviour of human adipose-derived mesenchymal stem cells on decellularized whole tissue and organ will have a positive impact on regenerative medicine. This review offers a current perspective about decellularization of animal tissues, stem cells' behaviors on obtained matrices and potential use of these matrices in human and/or animal clinic.trinfo:eu-repo/semantics/closedAccessDecellularizationExtracellular matrixAdipose derived mesenchymal stem cellBiomaterialTissue engineeringRegenerative medicineArticle21113914510.9775/kvfd.2014.11663Q4WOS:0003491902000252-s2.0-84910093934165383Q3