Yildiz, M.Yilmaz, S.Dolger, B.2025-01-272025-01-2720071070-3632https://doi.org/10.1134/S1070363207120079https://hdl.handle.net/20.500.12428/255102-(4-Chloro and 4-fluorophenylamino)-2,4,4,6,6-pentachloro-1,3,5,2 lambda(5),4 lambda(5),6 lambda(5)-triazatriphosphinines and poly [bis(4-fluoropwhenylamino)phosphazene] were synthesized by reactions of 4-fluoroaniline and 4-chloroaniline with 2,2,4,4,6,6-hexachloro-1,3,5,2 lambda(5),4 lambda(5),6 lambda(5)-triazatriphosphinine and poly(dichlorophosphazene), respectively, in tetrahydrofuran under argon at -20 degrees C, followed by heating under reflux. The products were isolated by column chromatography and were characterized by FTIR, NMR (H-1, C-13, P-31), and mass spectra, termogravimetry, and high-performance liquid chromatography. Antimicrobial activity of the monomeric compounds and polymer against 9 bacteria and 5 yeast cultures was evaluated by the disk diffusion method in dimethyl sulfoxide relative to a number of commercial antibiotics and antifungal agents. Aminophosphazene derivatives exhibited a broad spectrum of activity against both Gram-positive and Gram-negative bacterial with a magnitude comparable to reference antimicrobial agents. The polymeric product turned out to be more potent than the monomeric compounds.eninfo:eu-repo/semantics/closedAccessPhosphorus-Nitrogen CompoundsCyclophosphazenesPolyphosphazenesHexachlorocyclotriphosphazatrieneProductsPolymerArticle77122117212210.1134/S1070363207120079Q4WOS:0002528525000072-s2.0-38849117174Q3