Şahiner, NurettinKravitz, Daniel J.Qadir, RabahBlake, Diane A.Haque, SalimaJohn, Vijay T.Margo, Curtis E.2025-01-272025-01-2720090003-99501538-3601https://doi.org/10.1001/archophthalmol.2009.19https://hdl.handle.net/20.500.12428/2466118th Annual Meeting of the American-Glaucoma-Society -- MAR 06-09, 2008 -- Washington, DCObjective: To create and test a slow-release antifibrotic drug-coated glaucoma drainage device using in vitro and in vivo experiments. Methods: A slow-release device incorporating mitomycin C in poly(2-hydroxyethyl methacrylate) disks was developed using redox-polymerization techniques. A standardized preparation of this drug delivery device was attached to the Ahmed glaucoma valve (model FP7; New World Medical, Inc, Rancho Cucamonga, California). Semicircular disks (5 x 6 mm) of P(HEMA)-mitomycin C containing varying concentrations of mitomycin C per gram dry weight of the gel were attached to the lower half of an Ahmed glaucoma valve plate. Water was pumped through the modified Ahmed glaucoma valve at a rate comparable to that of aqueous humor outflow, and mitomycin C release was measured. Modified and unmodified Ahmed glaucoma valves were implanted in a rabbit model, and drug release and fibrosis were assessed after 3 months. Results: The P(HEMA)-mitomycin C device released mitomycin C in vitro over 1 to 2 weeks. Studies in rabbits revealed that mitomycin C was released from the disks during the 3-month implantation. Histologic analysis demonstrated a significant reduction in inflammatory reaction and fibrosis in the resulting blebs. Conclusion: Our slow-release drug-coated glaucoma drainage device decreased fibrosis and inflammation in the resulting bleb in a rabbit model. Clinical Relevance: This device could reduce the failure rate of glaucoma drainage devices.eninfo:eu-repo/semantics/closedAccessMitomycin-CDifferent BiomaterialsAhmed GlaucomaSurgeryValvePolypropyleneOutcomesImplantSocietyConference Object127444845310.1001/archophthalmol.2009.19Q1WOS:0002651034000132-s2.0-6524918878219365022N/A