Özsoy, FatmaÖzay, Özgür2024-01-242024-01-242023Özsoy, F., & Özay, Ö. (2023). Phosphazene-based nanostructures modified with gold nanoparticles as drug and gene carrier materials with antibacterial and antifungal properties. International Journal of Polymeric Materials and Polymeric Biomaterials, 1–12. https://doi.org/10.1080/00914037.2022.21636420091-40371563-535Xhttps://doi.org/10.1080/00914037.2022.2163642https://hdl.handle.net/20.500.12428/5397In this study, monodisperse spherical particles were synthesized by using hexachlorocyclotriphosphazene (HCCP) and 1-(2-Aminoethyl) piperazine (AEP) by the polycondensation reaction. Then, the surfaces of the synthesized nanospheres were functionalized with gold nanoparticles. Phz-AEP nanospheres and phz-AEP@Au nanocomposite were characterized by various methods. Drug release studies for the synthesized phz-AEP and phz-AEP@Au nanospheres were performed using a ribonucleic acid (RNA) and sodium diclofenac (NaDc). As a result of the release studies, the drug release kinetics of the nanospheres were investigated. Additionally, the antibacterial and antifungal effects of the synthesized phz-AEP and phz-AEP@Au nanocomposite spheres were tested.eninfo:eu-repo/semantics/closedAccessDrug releaseFunctional materialGold nanoparticlePhosphazeneRNAArticle11210.1080/00914037.2022.2163642Q2WOS:0009156716000012-s2.0-85147013389