Berber, NurcanSahutoglu, Arif SercanGokce, BasakCikrikci, KuebraGencer, Nahit2025-01-272025-01-2720230022-28601872-8014https://doi.org/10.1016/j.molstruc.2023.136061https://hdl.handle.net/20.500.12428/25982Phenylthiazol-2(3h)-ylidene-isoquinoline-5-amine derivatives(5a-r) were easily prepared from 5-aminoisoquinoline, thioisocyanate, and phenacyl bromide derivatives in the presence of triethylamine in tetrahydrofuran (THF), and dimethyl formamide (DMF) in two steps. In the first step, thiourea was synthesized in THF reflux, 24 h and then in the second step, the formation of thiazole ring was ensured in EtOH-DMF (5:5 v/v), reflux, 24 h. The newly synthesized compounds were characterized using 1H NMR, 13C NMR, IR, and elemental analysis. The inhibitory effects of 18 newly synthesized compounds (5a-r) on hydratase and esterase activities of carbonic anhydrase isoenzymes (hCA I, II, IX, and X) were studied in vitro.eninfo:eu-repo/semantics/closedAccessIsoquinolineThiazoleThioureaCarbonic anhydraseEnzyme inhibitorArticle129110.1016/j.molstruc.2023.136061Q2WOS:0010363787000012-s2.0-85163542622Q1