Koçak, Mehmet N.Malçok, Ümit A.Şahin, Mehmet H.Karaavcı, Nuh C.Çelik, MineDemirtaş, RabiaAydın, Mehmet D.2023-07-172023-07-172021Koçak, M. N., Malçok, U. A., Şahin, M. H., Karaavcı, N. C., Çelik, M., Demirtaş, R., & Aydın, M. D. (2021). Burned spinal cord in acidotic cerebrospinal fluid during subarachnoid hemorrhage: Experimental study. Cirugia y Cirujanos (English Edition), 89(5), 583-587. doi:10.24875/CIRU.200006270009-7411https://doi.org/10.24875/CIRU.20000627https://hdl.handle.net/20.500.12428/4405Objective: We investigated the effect of carotid body ischemia-induced cerebrospinal fluid acidosis on spinal cord during subarachnoid hemorrhage (SAH). Methods: Twenty-three hybrid rabbits were divided into three groups: control (n = 5), Sham (injected with 0.5 ml isotonic) (n = 6), and the SAH (n = 12) (injected with 0.5 ml autologous blood into the 4th ventricle) and then monitored for 3 weeks. Cerebrospinal fluid pH and degenerated ependymal cell density and volume of cervical central canal were analyzed. Results: The mean cervical central canal volumes, degenerated ependymal cells densities, and cerebrospinal pH values were 1.056 ± 0.053 mm3-6 ± 2 per mm2-7.342 ± 0.034, 1.321 ± 0.12 mm3-35 ± 9 per mm2-7.314 ± 0.056, and 1.743 ± 0.245 mm3-159 ± 24 per mm2-7.257 ± 0.049 in the Control, Sham, and SAH groups, respectively. The more degenerated carotid body neuron density induced decreased cerebrospinal fluid pH values (p < 0.0001) could result in the more ependymal cells desquamation (p < 0.0005) and central canal dilatation (p < 0.00001). Conclusion: Increased neurodegeneration of carotid bodies can reduce cause cerebrospinal fluid pH-induced ependymal cell degeneration and central canal dilatation following SAH.eninfo:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivs 3.0 United StatesAcidosisCarotid bodySpinal cordSubarachnoid hemorrhageArticle89558358710.24875/CIRU.20000627Q4WOS:0007070587000032-s2.0-8511859542034665180