Fisher, Marlie H.Ohmes, Lucas B.Yang, Jerry H.Le, ElliotColakoglu, SalihFrench, MackenzieSiddikoglu, Duygu2025-01-272025-01-2720241748-68151878-0539https://doi.org/10.1016/j.bjps.2024.01.033https://hdl.handle.net/20.500.12428/23820Background: The deep inferior epigastric perforator (DIEP) free flap is the gold standard procedure for autologous breast reconstruction. Although breast-related complications have been well described, donor-site complications and contributing patient risk factors are poorly understood. Methods: We examined a multi-institutional, prospectively maintained database of patients undergoing DIEP free flap breast reconstruction between 2015 and 2020. We evaluated patient modeling was used to predict donor-site outcomes based on patient characteristics. Results: A total of 661 patients were identified who underwent DIEP free flap breast reconstruction across multiple institutions. Using logistic regression modeling, we found that body mass index (BMI) was an independent risk factor for umbilical complications (odds ratio [OR] 1.11, confidence interval [CI] 1.04-1.18, p = 0.001), seroma (OR 1.07, CI 1.01-1.13, p = 0.003), wound dehiscence (OR 1.10, CI 1.06-1.15, p = 0.001), and surgical site infection (OR 1.10, CI 1.05-1.15, p = 0.001) following DIEP free flap breast reconstruction. Further, immediate reconstruction decreases the risk of abdominal bulge formation (OR 0.22, CI 0.108-0.429, p = 0.001). Perforator selection was not associated with abdominal morbidity in Conclusions: Higher BMI is associated with increased abdominal donor-site complications following DIEP free flap breast reconstruction. Efforts to lower preoperative BMI may help de (c) 2024 Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.eninfo:eu-repo/semantics/closedAccessBreast reconstructionDeep inferior epigastric perforator flapHerniaAbdominal wallBulgeArticle90889410.1016/j.bjps.2024.01.033N/AWOS:00118489460000138364673