Ocak, ÖzgülŞahin, Erkan Melih2025-01-272025-01-2720211307-2048https://doi.org/10.21763/tjfmpc.890372https://search.trdizin.gov.tr/tr/yayin/detay/460543https://hdl.handle.net/20.500.12428/15399Introduction: Alzheimer's disease is a progressive neurodegenerative disease that causes cognitive dysfunction. Cognitive impairment may be associatedwith vitamin D deficiency. This study aims to determine vitamin D levels and frequency of deficiency in Alzheimer's patients and to compare it with otherpatients of similar age group applied to the neurology clinic.Methods: The hospital records of patients who were seen in the neurology clinic between 01/01/2018 and 31/12/2020 and of whom 25 (OH) Vitamin D3levels were measured were included. In addition to Alzheimer's patients, the control group was randomly selected from the records of patients with nocognitive disorder with similar age and gender.Results: Of patients, 156 records were included in the Alzheimer group and 442 in the control group. There were 95 women (60.9%) 61 men (39.1%) in theAlzheimer group, 271 women (61.3%) 171 men (38.7%) in the control group. There was no significant difference between the mean age of the Alzheimergroup (75.9) and control group (75.4). No significant difference was detected between the mean vitamin D levels of Alzheimer's patients (21.5±12.4 ng/ml)and control group (20.1±13.1 ng/ml). There was no significant difference between the genders. Vitamin D levels of “85 years and above” were significantlylower than those of the \"75-79 years old\", \"70-74 years\" and \"65-69 years old\" groups.Conclusion: The mechanisms of vitamin D on the pathophysiologic pathways of Alzheimer disease have not been fully elucidated. According to our results,vitamin D levels are not significantly different between Alzheimer's patients and controls. Low vitamin D may be an effective factor in the development ofAlzheimer's disease, but after the disease occurs, vitamin D levels do not differ from other patients of similar age and gender.eninfo:eu-repo/semantics/openAccessNörolojik BilimlerArticle15354054510.21763/tjfmpc.890372460543