Pek, ErenBeyazıt, FatmaSıddıkoğlu, Duygu2024-01-222024-01-222023Pek, E., Beyzait, F., & Sıddıkoğlu, D. (2023). Is it possible to predict the success of single dose methotrexate in the treatment of tubal ectopic pregnancies? Ginekologia Polska, 94(3), 249–257. https://doi.org/10.5603/GP.a2023.00040017-00112543-6767https://doi.org/10.5603/GP.a2023.0004https://hdl.handle.net/20.500.12428/5302Objectives: In this study, the aim was to determine whether the use of endometrial thickness or neutrophil/lymphocyte and platelet/lymphocyte ratio would be useful in predicting the success of methotrexate in the treatment of ectopic pregnancies located in the fallopian tubes.Materal and methods:This study was carried out by retrospectively examining 68 study group cases with an ultrasono-graphically detectable gestational sac in the fallopian tubes and 189 control group cases with an unruptured ectopic pregnancy diagnosis at any location. The cut-off value of endometrial thickness was calculated as a new marker between the cases in which single-dose methotrexate treatment was successful and the cases with treatment failure. Treatment success was evaluated with different models including endometrial thickness, fetal cardiac activity status, measurable crown-rump length, and [3-hCG.Result: The cut-off value of [3-hCG for treatment success was determined as 2960.5 ng/mL, and the cut-off value for endometrial thickness was determined as 10.5 mm. Although NLR seems to be a marker with a cut-off value of 2.49, it does not provide an extra benefit in combined use as it is not a specific predictor. The highest success in predicting treat-ment success was achieved in the modeling in which crown-rump length + fetal cardiac activity + [3-hCG + endometrial thickness were used together.Conclusions: The use of endometrial thickness as a marker seems to be quite reliable in predicting treatment success. And we think it would be beneficial to thin the endometrium before using methotrexate.eninfo:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivs 3.0 United StatesEctopic pregnancyEndometrial thicknessHuman chorionic gonadotropin-βNeutrophil-lymphocyte ratioPlatelet-lymphocyte ratioPrognostic endometrial knownledgeSingle-dose methotrexateArticle94324925710.5603/GP.a2023.0004Q4WOS:0009709558000012-s2.0-8515239097636929795