Suner, Selin S.Şahiner, MehtapMohapatra, SubhraAyyala, Ramesh S.Bhethanabotla, Venkat R.Şahiner, Nurettin2023-06-072023-06-072021Suner, S. S., Sahiner, M., Mohapatra, S., Ayyala, R. S., Bhethanabotla, V. R., & Sahiner, N. (2022). Degradable poly(catechin) nanoparticles as a versatile therapeutic agent. International Journal of Polymeric Materials and Polymeric Biomaterials, 71(14), 1104-1115. doi:10.1080/00914037.2021.19419570091-40371563-535Xhttps://doi.org/10.1080/00914037.2021.1941957https://hdl.handle.net/20.500.12428/4261Poly(catechin) (p(CAT)) nanoparticles (NPs), 173 +/- 4 nm was prepared as a therapeutic agent with hydrolytic degradability affording sustainable CAT release over 20 d at carcinogenic conditions, pH 5.5 and 37.5 degrees C. Cell viability studies on MC38 colon cancer cells revealed the anticancer potential of p(CAT) NPs with 691 mu g/mL IC50 value while being well-tolerated by nonmalignant CCD841 CoN colon cells at 72 h incubation-time. P(CAT) NPs showed effective antioxidant capacity with 241 +/- 7 and 456 +/- 54 mu g/mL of GA equivalency of total phenol content (TPC), and total flavonoid content (TFC) values and 1.19 +/- 0.8 mu mol/g Trolox equivalent antioxidant capacity by 2,2'-Azino-bis-(3-ethylbenzothioazoline-6-sulfonic acid (ABTS(center dot+)) scavenging assay.eninfo:eu-repo/semantics/closedAccessantidiabeticantioxidantcancer therapyCAT nanoparticlesCatechinmetal chelatingArticle71141104111510.1080/00914037.2021.1941957Q3WOS:0006723939000012-s2.0-85110850086