Sariyilmaz, OznurUslu, GulsahSariyilmaz, EvrenKeskin, Neslihan Busra2025-01-272025-01-2720241432-69811436-3771https://doi.org/10.1007/s00784-024-05878-xhttps://hdl.handle.net/20.500.12428/21491ObjectivesThis study aimed to assess the efficacy of different activation techniques in removing calcium hydroxide (Ultracal XS), Ledermix, and Bio-C Temp from simulated internal root resorption (IRR) cavities.Materials and methods108 single-rooted maxillary incisors were prepared using Reciproc R50 files. Simulated IRR cavities, 2 mm in diameter and located 8 mm from the apex, were created. Ultracal XS, Ledermix, and Bio-C Temp were applied to the samples, grouped by irrigation activation techniques: Standard Needle Irrigation (SNI), EDDY, Passive Ultrasonic Irrigation (PUI), and XP-endo Finisher (XPF). Medicament removal efficacy was evaluated using a standardized scoring system. Statistical analysis was performed using the Kruskal-Wallis test.ResultsXPF and PUI were more effective than SNI in medicament removal across the groups, with no significant difference. EDDY showed no significant difference than other groups. Ledermix was more effectively removed in all activation groups compared to Bio-C Temp. The XPF was superior in removing Ultracal XS compared to Bio-C Temp. However, none of the groups achieved complete medicament removal.ConclusionsXPF and PUI techniques enhance medicament removal efficacy. Bio-C Temp was more difficult to remove from the IRR cavities than other medicaments.Clinical relevanceBio-C Temp could be removed from the canals less effectively compared to calcium hydroxide and Ledermix. Among the tested irrigation activation methods, XPF and PUI were found to be more effective at removing the tested medicaments.eninfo:eu-repo/semantics/closedAccessInternal root resorptionBio-C tempCalcium hydroxideEDDYLedermixXP-Endo finisherPassive ultrasonic activationArticle28910.1007/s00784-024-05878-xN/AWOS:0012927233000012-s2.0-8520152363739155361Q1