Self-Crosslinked Ellipsoidal Poly(Tannic Acid) Particles for Bio-Medical Applications

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dc.authorid0000-0003-0120-530Xen_US
dc.authorscopusid6602001525en_US
dc.authorwosidDVD-0927-2022en_US
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2023-06-23T11:50:24Z
dc.date.available2023-06-23T11:50:24Z
dc.date.issued2021en_US
dc.departmentRektörlük, Rektörlüğe Bağlı Bölümler, Nanobilim ve Teknoloji Araştırma ve Uygulama Merkezi
dc.description.abstractSelf-crosslinking of Tannic acid (TA) was accomplished to obtain poly(tannic acid) (p(TA)) particles in single step, surfactant free media using sodium periodate (NaIO4 ) as an oxidizing agent. Almost monodisperse p(TA) particles with 981 ± 76 nm sizes and −22 ± 4 mV zeta potential value with ellipsoidal shape was obtained. Only slight degradation of p(TA) particles with 6.8 ± 0.2% was observed at pH 7.4 in PBS up to 15 days because of the irreversible covalent formation between TA units, suggesting that hydrolytic degradation is independent from the used amounts of oxidation agents. p(TA) particles were found to be non-hemolytic up to 0.5 mg/mL concentration and found not to affect blood clotting mechanism up to 2 mg/mL concentration. Antioxidant activity of p(TA) particles was investigated by total phenol content (TPC), ferric reducing antioxidant potential (FRAP), trolox equivalent antioxidant capacity (TEAC), total flavanoid content (TFC), and Fe (II) chelating activity. p(TA) particles showed strong antioxidant capability in comparison to TA molecules, except FRAP assay. The antibacterial activity of p(TA) particles was investigated by micro-dilution technique on E. coli as Gram-negative and S. aureus as Gram-positive bacteria and found that p(TA) particles are more effective on S. aureus with over 50% inhibition at 20 mg/mL concentration attained.en_US
dc.identifier.citationŞahiner, N. (2021). Self-crosslinked ellipsoidal poly(tannic acid) particles for bio-medical applications. Molecules, 26(9) doi:10.3390/molecules26092429en_US
dc.identifier.doi10.3390/molecules26092429
dc.identifier.issn1420-3049
dc.identifier.issue9en_US
dc.identifier.pmid33921976
dc.identifier.scopus2-s2.0-85105179674
dc.identifier.urihttps://doi.org/10.3390/molecules26092429
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4337
dc.identifier.volume26en_US
dc.identifier.wosWOS:000650655600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞahiner, Nurettin
dc.language.isoen
dc.publisherMDPI AGen_US
dc.relation.ispartofMoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectAntibacterialen_US
dc.subjectAntioxi-danten_US
dc.subjectBio-medicinal applicationsen_US
dc.subjectPolyphenolic microgel/nanogelen_US
dc.subjectSelf-crosslinked flavonoiden_US
dc.subjectTannic acid particlesen_US
dc.titleSelf-Crosslinked Ellipsoidal Poly(Tannic Acid) Particles for Bio-Medical Applications
dc.typeArticle

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