Synthesis and Characterization of Novel pH-Responsive Poly(2-hydroxylethyl methacrylate-co-N-allylsuccinamic acid) Hydrogels for Drug Delivery

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dc.contributor.authorÖzay, Özgür
dc.date.accessioned2025-01-27T20:11:49Z
dc.date.available2025-01-27T20:11:49Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, N-allylsuccinamic acid (NASA) was synthesized in a single step with a yield of 85%. Carboxylic acid containing NASA was characterized through Fourier transform infrared (FTIR) radiation and H-1-NMR and C-13-NMR analysis, and then it was used for synthesis of poly(2-hydroxylethyl methacrylate-co-N-allylsuccinamic acid) [p(HEMA-co-NASA)] hydrogels. The structure of the obtained pH-responsive p(HEMA-co-NASA) hydrogels were characterized with FTIR spectroscopy and scanning electron microscopy analysis, and their swelling characterization was carried out under different drug-release conditions. In the application step of the study, the hydrogels were used for the in vitro release of vitamin B12 and Rhodamine 6G, which were selected as model drugs. We determined that the hydrogels used as a drug-delivery matrix could release the drug they had absorbed under different release conditions (phosphate-buffered saline, 0.9% NaCl, and pH 1.2) at high rates for time periods of up to 24 h. (C) 2013 Wiley Periodicals, Inc.
dc.identifier.doi10.1002/app.39660
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue1
dc.identifier.scopus2-s2.0-84885954840
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/app.39660
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20739
dc.identifier.volume131
dc.identifier.wosWOS:000336254700024
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Applied Polymer Science
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectadsorption
dc.subjectdrug-delivery systems
dc.subjectgels
dc.subjectswelling
dc.titleSynthesis and Characterization of Novel pH-Responsive Poly(2-hydroxylethyl methacrylate-co-N-allylsuccinamic acid) Hydrogels for Drug Delivery
dc.typeArticle

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