Improved Biomedical Properties of Polydopamine-Coated Carbon Nanotubes

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dc.authorid0000-0001-7083-1481en_US
dc.authorid0000-0001-8666-7954en_US
dc.authorid0000-0002-3524-0675en_US
dc.authorid0000-0003-0120-530Xen_US
dc.authorscopusid56026625600en_US
dc.authorscopusid24472372400en_US
dc.authorscopusid57210429765en_US
dc.authorscopusid6602001525en_US
dc.authorwosidHQZ-4087-2023en_US
dc.authorwosidAAB-6714-2020en_US
dc.authorwosidU-5886-2019en_US
dc.authorwosidDVD-0927-2022en_US
dc.contributor.authorDemirci, Şahin
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2023-07-11T08:29:40Z
dc.date.available2023-07-11T08:29:40Z
dc.date.issued2021en_US
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümü
dc.departmentRektörlük, Rektörlüğe Bağlı Bölümler, Nanobilim ve Teknoloji Araştırma ve Uygulama Merkezi
dc.description.abstractCarbon nanotubes (CNTs) due to their outstanding mechanical, thermal, chemical, and optical properties were utilized as a base material and were coated with polydopamine (PDA) (PDA@CNT) via the simple self-polymerization of dopamine (DA). Then, PDA@CNT coatings of up to five layers were examined for potential biomedical applications. The success of multiple coating of CNTs with PDA was confirmed via increased weight loss values with the increased number of PDA coatings of CNTs at 500◦C by thermogravimetric analysis. The surface area of bare CNTs was measured as 263.9 m2/g and decreased to 197.0 m2/g after a 5th coating with PDA. Furthermore, the antioxidant activities of CNT and PDA@CNTs were determined via total flavonoid content (TFC), total phenol content (TPC), and Fe(III)-reducing antioxidant power (FRAP) tests, revealing the increased antioxidant ability of PDA@CNTs with the increasing numbers of PDA coatings. Moreover, a higher inhibition percentage of the activity of the alpha-glucosidase enzyme with 95.1 ± 2.9% inhibition at 6 mg/mL PDA-1st@CNTs concentration was found. The CNT and PDA@CNTs exhibited blood compatibility, less than a 2.5% hemolysis ratio, and more than 85% blood clotting indexes. The minimum inhibition concentration (MIC) of PDA-5th@CNTs against E. coli and S. aureus bacteria was determined as 10 mg/mL.en_US
dc.identifier.citationDemirci, S., Şahiner, M., Sağbaş Suner, S., & Şahiner, N. (2021). Improved biomedical properties of polydopamine-coated carbon nanotubes. Micromachines, 12(11) doi:10.3390/mi12111280en_US
dc.identifier.doi10.3390/mi12111280
dc.identifier.issn2072-666X
dc.identifier.issue11en_US
dc.identifier.pmid34832691
dc.identifier.scopus2-s2.0-85118133158
dc.identifier.urihttps://doi.org/10.3390/mi12111280
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4358
dc.identifier.volume12en_US
dc.identifier.wosWOS:000725542600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDemirci, Şahin
dc.institutionauthorŞahiner, Mehtap
dc.institutionauthorSağbaş Suner, Selin
dc.institutionauthorŞahiner, Nurettin
dc.language.isoen
dc.publisherMDPIen_US
dc.relation.ispartofMicromachinesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectBiomedicalen_US
dc.subjectCarbon nanotubesen_US
dc.subjectCoatingen_US
dc.subjectPDA@CNTen_US
dc.subjectPolydopamineen_US
dc.titleImproved Biomedical Properties of Polydopamine-Coated Carbon Nanotubes
dc.typeArticle

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