Nitrogen and Sulfur Doped Carbon Dots from Amino Acids for Potential Biomedical Applications

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dc.authoridSılan, Coşkun / 0000-0002-8352-6571
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.authoridŞahiner, Mehtap / 0000-0001-8666-7954
dc.contributor.authorŞahiner, Nurettin
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorSılan, Coşkun
dc.date.accessioned2025-01-27T20:54:05Z
dc.date.available2025-01-27T20:54:05Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractNitrogen (N-) and sulfur (S-) doped carbon dots (CDs) were synthesized in a single step in a few min, 1-4 min via microwave technique from five different types of amino acids viz. Arginine (A), Lysine (L), Histidine (H), Cysteine (C), and Methionine (M). These amino acid derived N- and/or S- doped CDs were found to be in spherical shapes with 5-20 nm particle size range determined by Transition Electron Microscope (TEM) images and Dynamic Light Scattering (DLS) measurements. Thermal degradation, functional groups, and surface potential of the CDs were determined by Thermogravimetric Analysis (TGA), FT-IR spectroscopy, and zeta potential measurements, respectively. Although the zeta potential value of Cysteine derived CD (C-CD) was measured as -7.45 +/- 1.32 mV, the zeta potential values of A-CD, L-CD, H-CD, and M-CD particles were measured as +2.84 +/- 0.67, +2.61 +/- 1.0, +4.10 +/- 1.50 and+2.20 +/- 0.60 mV, respectively. Amongst the CDs, C- CDs was found to possess the highest quantum yield, 89%. Moreover, the blood compatibility test of CDs, determined with hemolysis and blood clotting tests was shown that CDs at 0.25 mg/mL concentration, CDs has less than 5% hemolysis ratio and higher than 50% blood clotting indexes. Furthermore, A-CD was modified with polyethyleneimine (PEI) and was found that the zeta potential values was increased to +34.41 +/- 4.17 mV (from +2.84 +/- 0.67 mV) inducing antimicrobial capability to these materials. Minimum Inhibition Concentration (MIC) of A-CD dots was found as 2.5 mg/mL whereas the PEI modified A-CDs, A-CD-PEI was found as 1 mg/mL against Escherichia coli ATCC 8739 (gram -) and Staphylococcus aureus ATCC 6538 (gram +) bacteria strains signifying the tunability of CDs.
dc.description.sponsorshipCanakkale Onsekiz Mart University [COMU BAP, TSA-2018-2457] Funding Source: Medline
dc.identifier.doi10.1007/s10895-019-02431-y
dc.identifier.endpage1200
dc.identifier.issn1053-0509
dc.identifier.issn1573-4994
dc.identifier.issue5
dc.identifier.pmid31502060
dc.identifier.scopus2-s2.0-85072045722
dc.identifier.scopusqualityQ3
dc.identifier.startpage1191
dc.identifier.urihttps://doi.org/10.1007/s10895-019-02431-y
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25970
dc.identifier.volume29
dc.identifier.wosWOS:000496320700013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofJournal of Fluorescence
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectFluorescence carbon dots
dc.subjectAmino acid derived CDs
dc.subjectMicrowave technique
dc.subjectBlood compatibility
dc.subjectAntimicrobial CDs
dc.titleNitrogen and Sulfur Doped Carbon Dots from Amino Acids for Potential Biomedical Applications
dc.typeArticle

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