The Effect of Royal Jelly on Telomere Length and Some Biochemical Parameters in Wistar Albino Rats with Liver Damage Caused by Carbon Tetrachloride

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dc.authorid, SELCEN/0000-0002-6474-9032
dc.contributor.authorcakir, Selcen
dc.date.accessioned2025-01-27T20:17:06Z
dc.date.available2025-01-27T20:17:06Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractRoyal jelly (RJ) is a natural bee product that has been used for therapeutic purposes since ancient times. The therapeutic properties of this product, which has rich biological content, are still being investigated with new approaches. In this study, the effect of RJ on telomere length, some antioxidant parameters, and lipid profile was examined. This study will contribute to the literature as it is the first to evaluate the effect of RJ on the length of telomeres in damaged liver tissues. In the study, the levels of serum triglyceride, total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), aspartate transaminase (AST), alanine transaminase (ALT), telomerase, 8 & PRIME;-hydroxy-2 & PRIME;-deoxyguanosine (8-OHdG), and paraoxonase-1 (PON1) were investigated with enzyme-linked immunosorbent assay method and telomere lengths were investigated by real-time quantitative polymerase chain reaction. The increased TC, LDL-C levels, and AST and ALT activities in the serum after carbon tetrachloride (CCl4) administration approached the control level after RJ administration. PON1 activity decreased in groups with CCl4. PON1 activity increased after RJ administration. The level of 8-OHdG, which increased groups with CCl4, decreased after RJ administration. According to the results of telomere length analysis in liver tissues, telomere lengths in damaged tissues were significantly shortened with CCl4 application and increased with RJ application. Based on the findings of the study, it was concluded that RJ may have therapeutic effects on telomere lengths and some biochemistry parameters.
dc.description.sponsorshipCxanakkale Onsekiz Mart University Scientific Research department [TSA-2020-3150]
dc.description.sponsorshipThis study was supported by Cxanakkale Onsekiz Mart University Scientific Research department with project No.TSA-2020-3150.
dc.identifier.doi10.1089/jmf.2023.0042
dc.identifier.endpage585
dc.identifier.issn1096-620X
dc.identifier.issn1557-7600
dc.identifier.issue8
dc.identifier.pmid37477674
dc.identifier.startpage580
dc.identifier.urihttps://doi.org/10.1089/jmf.2023.0042
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21489
dc.identifier.volume26
dc.identifier.wosWOS:001033208500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofJournal of Medicinal Food
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectbiochemical parameters
dc.subjectcarbon tetrachloride
dc.subjectliver damage
dc.subjectroyal jelly
dc.subjecttelomere length
dc.titleThe Effect of Royal Jelly on Telomere Length and Some Biochemical Parameters in Wistar Albino Rats with Liver Damage Caused by Carbon Tetrachloride
dc.typeArticle

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