Super porous α-, β-, γ-cyclodextrin cryogels with high active agent loading and controllable release profiles

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dc.authoridYılmaz, Aynur S. / 0000-0002-8631-8479
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorYılmaz, Aynur S.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:26:56Z
dc.date.available2025-01-27T20:26:56Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractCyclodextrins (CDs) are truncated cone-like structures that are natural cyclic oligosaccharides. Here, a simple preparation method for super porous poly(alpha-CD), poly(beta-CD), and poly(gamma-CD) cryogels crosslinking with divinyl sulfone at 150%, 100% and 125% mole ratios with respect to the alpha-CD, beta-CD, and gamma-CD molecules, respectively, under cryogenic conditions, is reported. The interconnected homogeneous pore distribution of CD-based cryogels with pore sizes in the range of 5-100 mu m is confirmed by SEM analysis. The CD-based cryogels weighing 10 mg are determined as hemocompatible with <1% hemolysis ratios and >79% blood clotting indexes; whereas the same materials weighing 1 mg are biocompatible with >75% cell viability on L929 fibroblasts. Additionally, active agent adsorption/delivery efficiencies of CD-based cryogels utilizing two active agents, Bisphenol A (BPA, a carcinogenic compound) and Curcumin (CUR, a polyphenolic compound), are individually evaluated. It was revealed that p(gamma-CD) cryogels exhibited the highest active agent loading capacity for BPA, 87 +/- 13 mg/g, whereas p(alpha-CD) cryogels showed the highest loading capacity for CUR, 136 +/- 4 mg/g. Moreover, the active agent release from p(alpha-CD), p(beta-CD), and p(gamma-CD) cryogel networks at pH 7.4 and 37(degrees)C were determined as 40.6 +/- 2, 35.3 +/- 2, and 34 +/- 1 mg/g for BPA, and 1.07 +/- 0.2, 1.27 +/- 0.1, and 1.37 +/- 0.1 mg/g for CUR, respectively, within 96 h.
dc.description.sponsorshipThe authors are thankful to Dr. Sahin Demirci and Dr. Selin S Suner for their help in the synthesis of p(CD) cryogels and their blood compatibility and cell cytotoxicity studies.
dc.description.sponsorshipThe authors are thankful to Dr. Sahin Demirci and Dr. Selin S Suner for their help in the synthesis of p(CD) cryogels and their blood compatibility and cell cytotoxicity studies.
dc.identifier.doi10.1002/app.54822
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85174620666
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/app.54822
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22506
dc.identifier.volume141
dc.identifier.wosWOS:001089488100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Applied Polymer Science
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectBisphenol A
dc.subjectcontrollable active agent release
dc.subjectcryogel
dc.subjectcurcumin
dc.subjectcyclodextrins
dc.subjectsuper porous cyclodextrin network
dc.titleSuper porous α-, β-, γ-cyclodextrin cryogels with high active agent loading and controllable release profiles
dc.typeArticle

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