Effects of Carnosine, Ankaferd, and Silver Sulfadiazine on an Experimental Burn Model: Roles of Irisin and HSP70

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dc.authorid0000-0001-6513-0226en_US
dc.authorscopusid57218512156en_US
dc.authorwosid-en_US
dc.contributor.authorKocaman, Nevin
dc.contributor.authorAltun, Serdar
dc.contributor.authorBal, Ali
dc.contributor.authorÖzcan, Erhan Cahit
dc.contributor.authorSarac, Mehmet
dc.contributor.authorArtaş, Gökhan
dc.contributor.authorDemir, Betül
dc.contributor.authorAydın, Suüleyman
dc.contributor.authorKuloğlu, Tuncay
dc.date.accessioned2023-05-16T06:10:15Z
dc.date.available2023-05-16T06:10:15Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractIn this study, the effects of carnosine, ankaferd, and 1% silver sulfadiazine applied topically on second-degree burns were investigated and the roles of irisin and Heat shock protein 70 (HSP70) in this healing process were evaluated. Ninety male albino rats were used and divided into five groups. The groups were classified as control, burn, burn + carnosine (CAR), burn + ankaferd (ABS), and burn + silver sulfadiazine (SS). It was found that level of irisin increased in the first week and decreased in the second week in the burn and CAR groups. In the ABS and SS groups, the level of irisin was determined that started to increase in the first week and continued to increase in the second week. The level of HSP70 was found to increased in the first week in burn and CAR groups and decreased in the second week, but started to increase in the second week in ABS and SS groups. Both levels of irisin and HSP70 were observed to decreased in all treatment groups in the third week. In this study, it was shown that ankaferd and silver sülfadiazine treatments cause an increase in the irisin levels in the early period and a gradually increase in HSP70 levels in the later period in burns. The inflammatory response was observed to be limited in the early period in the ankaferd and sulfadiazin groups. It was concluded that these findings were effective in early wound healing in burns.en_US
dc.identifier.citationKocaman, N., Altun, S., Bal, A., Özcan, E. C., Sarac, M., Artas, G., . . . Kuloğlu, T. (2021). Effects of carnosine, ankaferd, and silver sulfadiazine on an experimental burn model: Roles of irisin and HSP70. Journal of Burn Care and Research, 42(3), 408-414. doi:10.1093/jbcr/iraa156en_US
dc.identifier.doi10.1093/jbcr/iraa156
dc.identifier.endpage414en_US
dc.identifier.issn1559-047X
dc.identifier.issn1559-0488
dc.identifier.issue3en_US
dc.identifier.pmid32910166
dc.identifier.scopus2-s2.0-85106538543
dc.identifier.startpage408en_US
dc.identifier.urihttps://doi.org/10.1093/jbcr/iraa156
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4151
dc.identifier.volume42en_US
dc.identifier.wosWOS:000683376000009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzcan, Erhan Cahit
dc.language.isoen
dc.publisherOxford University Pressen_US
dc.relation.ispartofJournal of Burn Care and Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBurns / drug therapyen_US
dc.subjectProtectsen_US
dc.subjectInjuryen_US
dc.subjectRatsen_US
dc.titleEffects of Carnosine, Ankaferd, and Silver Sulfadiazine on an Experimental Burn Model: Roles of Irisin and HSP70
dc.typeArticle

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