Synthesis and Characterization of Soft Polymeric Nanoparticles and Composites with Tunable Properties

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dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridIlgın, Pınar / 0000-0001-7071-0575
dc.contributor.authorŞahiner, Nurettin
dc.contributor.authorIlgın, Pınar
dc.date.accessioned2025-01-27T20:26:56Z
dc.date.available2025-01-27T20:26:56Z
dc.date.issued2010
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPolymeric particles comprising acrylonitrile (AN)based core and acrylamide derivative-based shell in the submicron range with positive and negative charges were synthesized via microemulsion polymerization. 2-Acrylamido-2methylpropane sulfonic acid (AMPS) and 3-(acrylamidopropyl)trimethyl ammonium chloride (APTMACl) were used as shell-forming charged monomers onto AN core for the synthesis of p(AN-co-AMPS) and p(AN-co-APTMACl), respectively, using an oil-in-water emulsion system. To tune the characteristics of the core-shell particles, AN moieties in the core were amidoximated to change the nature of the core from hydrophobic (nitrile) to hydrophilic (amidoxime) nature. Additionally, colloidal magnetite particles (Fe(3)O(4)) produced by chemical coprecipitation technique under alkaline and inert conditions were also included inside p(AN-co-AMPS) and p(AN-co-APTMACl) particles as dual-responsive nanocomposites against pH and magnetic field. With the magnetic properties, AN-based core with modifiable characteristics and acrylamide-based polyelectrolyte shells with variable charges and sizes were further used as drug carriers. For potential targeted drug delivery application of the synthesized soft particles and their composites Naproxen and Trimethoprim were used as model drugs, and he release studies were carried in phosphate buffer saline (pH 7.4) at ambient temperature. (C) 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 5239-5246, 2010
dc.description.sponsorshipTurkish Academy of Science (TUBA)
dc.description.sponsorshipN. Sahiner is grateful to the Turkish Academy of Science (TUBA) for the financial support under 2008-TUBA GEBIP program.
dc.identifier.doi10.1002/pola.24324
dc.identifier.endpage5246
dc.identifier.issn0887-624X
dc.identifier.issue22
dc.identifier.scopus2-s2.0-78649539777
dc.identifier.scopusqualityN/A
dc.identifier.startpage5239
dc.identifier.urihttps://doi.org/10.1002/pola.24324
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22511
dc.identifier.volume48
dc.identifier.wosWOS:000284109000036
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherJohn Wiley & Sons Inc
dc.relation.ispartofJournal of Polymer Science Part A-Polymer Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectdrug delivery systems
dc.subjectdrug targeting
dc.subjectfunctionalization of polymers
dc.subjectmagnetic polymers
dc.subjectmicrogels
dc.subjectmodifiable core-shell particles
dc.subjectnanocomposites
dc.subjectpolyelectrolyte particles
dc.subjectsoft and smart particles
dc.titleSynthesis and Characterization of Soft Polymeric Nanoparticles and Composites with Tunable Properties
dc.typeArticle

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