One step preparation of polymeric maltitol particles, from a sugar molecule, maltitol for biomedical applications

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dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:39:07Z
dc.date.available2025-01-27T20:39:07Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractHere, a facile method for the preparation of polymeric particles from a sugar molecule, maltitol (ML) in single step was reported via microemulsion polymerization/crosslinking technique with a high yield, 89 +/- 6%. Furthermore, poly(Maltitol) (p(ML)) particles were chemically modified to induce different physicochemical characteristic using different anionic and cationic modifying agents such as taurine (TA) and diethylenetriamine (DETA) to prepare m-p(ML)/TA and m-p(ML)/DETA. The blood compatibility of the p(ML) particles and their modified forms were tested with fresh blood, and found that p(ML) and m-(ML)/DETA particles are blood compatible with about 5% hemolysis, and above 80% blood clotting indices. Moreover, the cytotoxicity results against L929 fibroblast cell line revealed that p(ML) based particle are biocompatible up to 100 mu g/mL with 85% cell viability regardless of their nature, and at 200 mu g/mL dosage of p(ML), m-p(ML)/TA and m-p(ML)/DETA particles, the cell viabilities were determined as 83.33, 64.03 and 73.89% on for L929 fibroblast cells implying the slightly less biocompatibility nature of m-p(ML)/TA in accord with the blood compatibility results. Additionally, the apoptotic and necrotic indices were determination for p(ML) based particles on L929 fibroblast cells, and the results revealed that these particles do not induce any and stress on the cells. Also, it does not have genotoxic effect as determined against CHO cells.
dc.identifier.doi10.1016/j.msec.2018.04.017
dc.identifier.endpage212
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.pmid29752090
dc.identifier.scopus2-s2.0-85045409899
dc.identifier.scopusqualityN/A
dc.identifier.startpage205
dc.identifier.urihttps://doi.org/10.1016/j.msec.2018.04.017
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23864
dc.identifier.volume89
dc.identifier.wosWOS:000434239100022
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofMaterials Science & Engineering C-Materials For Biological Applications
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectSugar polymeric particle
dc.subjectP(maltitol) microgel/nanogel
dc.subjectBiocompatible, biodegradable and blood compatible p(maltitol)
dc.titleOne step preparation of polymeric maltitol particles, from a sugar molecule, maltitol for biomedical applications
dc.typeArticle

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