Targeting Gut Microbiota with Probiotics and Phenolic Compounds in the Treatment of Atherosclerosis: A Comprehensive Review

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dc.authoridKarav, Sercan / 0000-0003-4056-1673
dc.authoridDuman, Hatice / 0000-0002-4526-6609
dc.contributor.authorCruz Neto, Jose Patrocinio Ribeiro
dc.contributor.authorFreire, Micaelle Oliveira de Luna
dc.contributor.authorLemos, Deborah Emanuelle de Albuquerque
dc.contributor.authorAlves, Rayanne Maira Felix Ribeiro
dc.contributor.authorCardoso, Emmily Ferreira de Farias
dc.contributor.authorBalarini, Camille de Moura
dc.contributor.authorDuman, Hatice
dc.contributor.authorKarav, Sercan
dc.date.accessioned2025-01-27T20:35:15Z
dc.date.available2025-01-27T20:35:15Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAtherosclerosis (AS) is a chronic inflammatory vascular disease. Dysregulated lipid metabolism, oxidative stress, and inflammation are the major mechanisms implicated in the development of AS. In addition, evidence suggests that gut dysbiosis plays an important role in atherogenesis, and modulation of the gut microbiota with probiotics and phenolic compounds has emerged as a promising strategy for preventing and treating AS. It has been shown that probiotics and phenolic compounds can improve atherosclerosis-related parameters by improving lipid profile, oxidative stress, and inflammation. In addition, these compounds may modulate the diversity and composition of the gut microbiota and improve atherosclerosis. The studies evaluated in the present review showed that probiotics and phenolic compounds, when consumed individually, improved atherosclerosis by modulating the gut microbiota in various ways, such as decreasing gut permeability, decreasing TMAO and LPS levels, altering alpha and beta diversity, and increasing fecal bile acid loss. However, no study was found that evaluated the combined use of probiotics and phenolic compounds to improve atherosclerosis. The available literature highlights the synergistic potential between phenolic compounds and probiotics to improve their health-promoting properties and functionalities. This review aims to summarize the available evidence on the individual effects of probiotics and phenolic compounds on AS, while providing insights into the potential benefits of nutraceutical approaches using probiotic strains, quercetin, and resveratrol as potential adjuvant therapies for AS treatment through modulation of the gut microbiota.
dc.identifier.doi10.3390/foods13182886
dc.identifier.issn2304-8158
dc.identifier.issue18
dc.identifier.pmid39335815
dc.identifier.scopus2-s2.0-85205101187
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/foods13182886
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23609
dc.identifier.volume13
dc.identifier.wosWOS:001323814200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofFoods
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectatherosclerosis
dc.subjectnutraceuticals
dc.subjectgut microbiota
dc.subjectprobiotic
dc.subjectquercetin
dc.subjectresveratrol
dc.titleTargeting Gut Microbiota with Probiotics and Phenolic Compounds in the Treatment of Atherosclerosis: A Comprehensive Review
dc.typeReview Article

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