Chitosan based hybrid hydrogels for drug delivery: Preparation, biodegradation, thermal, and mechanical properties

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dc.authorid0000-0002-9813-2962en_US
dc.authorscopusid56250747600en_US
dc.authorwosidABD-2324-2020en_US
dc.contributor.authorKamacı, Musa
dc.contributor.authorKaya, İsmet
dc.date.accessioned2024-01-27T12:03:15Z
dc.date.available2024-01-27T12:03:15Z
dc.date.issued2023en_US
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümü
dc.description.abstractIn the present paper, biodegradable hybrid hydrogels were prepared by using chitosan as a natural polymer and polyurethane containing azomethine as a synthetic polymer for the drug delivery application for 5-fluorouracil. The fabricated hydrogels were characterized via FT-IR and SEM analysis. Besides, the thermal, mechanical, and wettability properties, water uptake, biodegradation, protein absorption, drug loading, and release behaviors of the hybrid hydrogels were studied. The obtained results indicated that the fabricated hybrid hydrogels have exhibited good mechanical, hydrophilic, water uptake, and biodegradation behaviors. The hybrid hydrogels also showed 50% drug release amounts and they could be a good candidate for the controlled delivery of 5-FU due to these properties.en_US
dc.identifier.citationKamacı, M., & İsmet, Kaya (2023). Chitosan based hybrid hydrogels for drug delivery: Preparation, biodegradation, thermal, and mechanical properties. Polymers for Advanced Technologies, 34(2), 779–788. https://doi.org/10.1002/pat.5930en_US
dc.identifier.doi10.1002/pat.5930
dc.identifier.endpage788en_US
dc.identifier.issn1042-7147
dc.identifier.issn1099-1581
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85142293444
dc.identifier.startpage779en_US
dc.identifier.urihttps://doi.org/10.1002/pat.5930
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5455
dc.identifier.volume34en_US
dc.identifier.wosWOS:000884141100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKaya, İsmet
dc.language.isoen
dc.publisherJohn Wiley and Sons Ltden_US
dc.relation.ispartofPolymers for Advanced Technologiesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/MAG215M714
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChitosanen_US
dc.subjectDrug deliveryen_US
dc.subjectHybrid hydrogelen_US
dc.subjectPolyurethaneen_US
dc.titleChitosan based hybrid hydrogels for drug delivery: Preparation, biodegradation, thermal, and mechanical properties
dc.typeArticle

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