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Possible protective activity of n‑acetyl cysteine against cisplatin‑induced hepatotoxicity in rats

Coşkun, Özlem; Öztopuz, Özlem; Büyük, Başak (Springer, 2021)

CP is one of the most widely used antineoplastic agents. However, its clinical application is very limited due to its severe toxic efects. The present study aimed to reveal the efects of NAC, which exhibits broad biological ...

Alterations in aquaporin gene expression level on cyclophosphamide-induced cardiac injury and possible protective role of Ganoderma lucidum

Öztopuz, Özlem; Coşkun, Özlem; Büyük, Başak (Springer, 2021)

This research study was conducted to investigate the cardioprotective activity of alcoholic extract of Ganoderma lucidum (GL) against cyclophosphamide (CYP)-induced cardiotoxicity in rats model. Therewithal, the regulation ...

The effect of medical ozone on oxidative stress and neuroinflammation in the early stage after experimental status epilepticus

Çokyaman, Turgay; Öztopuz, Özlem; Coşkun, Özlem; Büyük, Başak; Kiraz, Hasan Ali; Elmas, Sait (Springer, 2021)

Preservation of the brain is important to reducing recurrent seizures and other neurological sequelae after status epilepticus (SE). Medical ozone (MedO3) shows antioxidant, anti-inflammatory and anti-apoptotic properties ...

The Effect of Topically Applied Boric Acid on Ephrin-Eph Pathway in Wound Treatment: An Experimental Study

Büyük, Başak; Aydeğer, Cemre; Adalı, Yasemen; Eroğlu, Hüseyin Avni (SAGE Publications, Early Acce)

Background: Wound healing has a vital importance for the organism and various agents are used to accelerate wound healing. Although the effect of boron on wound healing is known, its mechanisms are not completely clear ...