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Possible protective activity of n‑acetyl cysteine against cisplatin‑induced hepatotoxicity in rats

Coşkun, Özlem; Öztopuz, Özlem; Büyük, Başak (Springer, 2021)

CP is one of the most widely used antineoplastic agents. However, its clinical application is very limited due to its severe toxic efects. The present study aimed to reveal the efects of NAC, which exhibits broad biological ...

Alterations in aquaporin gene expression level on cyclophosphamide-induced cardiac injury and possible protective role of Ganoderma lucidum

Öztopuz, Özlem; Coşkun, Özlem; Büyük, Başak (Springer, 2021)

This research study was conducted to investigate the cardioprotective activity of alcoholic extract of Ganoderma lucidum (GL) against cyclophosphamide (CYP)-induced cardiotoxicity in rats model. Therewithal, the regulation ...

The effect of medical ozone on oxidative stress and neuroinflammation in the early stage after experimental status epilepticus

Çokyaman, Turgay; Öztopuz, Özlem; Coşkun, Özlem; Büyük, Başak; Kiraz, Hasan Ali; Elmas, Sait (Springer, 2021)

Preservation of the brain is important to reducing recurrent seizures and other neurological sequelae after status epilepticus (SE). Medical ozone (MedO3) shows antioxidant, anti-inflammatory and anti-apoptotic properties ...

Melatonin ameliorates cardiac remodelling in fructose‑induced metabolic syndrome rat model by using genes encoding cardiac potassium ion channels

Ovalı, Mehmet Akif; Öztopuz, Özlem; Vardar, Selma Arzu (Springer, 2021)

Background Metabolic syndrome comprises a group of disorders, including cardiac abnormalities. Ventricular arrhythmias observed in metabolic syndrome are due to the impaired ventricular repolarization. This study aims to ...